RecG Directs DNA Synthesis during Double-Strand Break Repair

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RecG Directs DNA Synthesis during Double-Strand Break Repair

Homologous recombination provides a mechanism of DNA double-strand break repair (DSBR) that requires an intact, homologous template for DNA synthesis. When DNA synthesis associated with DSBR is convergent, the broken DNA strands are replaced and repair is accurate. However, if divergent DNA synthesis is established, over-replication of flanking DNA may occur with deleterious consequences. The R...

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Double strand break repair.

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ژورنال

عنوان ژورنال: PLOS Genetics

سال: 2016

ISSN: 1553-7404

DOI: 10.1371/journal.pgen.1005799